Warning About Methotrexate and Amoxicillin Interactions

Often times our ailments are associated with more than one type of symptoms, and the need to combine medications is a necessity. However not all medications are safe to use together. Your doctor will often balance out the side effects of the drugs before they can prescribe them to you. If the drugs are safe to use together, your doctor will still need to monitor the effects of the drug in your body, and do series of lab tests from time to time, depending on the gravity of your ailment and the type of drugs you are prescribed to take. For example, when you take medications used for treating bacterial infections such as amoxicillin, you have to take measures and precautions about which drug is safe to be taken together with this antibiotic. Among the most dangerous combination with amoxicillin is methotrexate. So why combining methotrexate and amoxicillin is such a bad idea? What are the possible methotrexate and amoxicillin interactions? First let us take a look at the uses of each drug.

What is amoxicillin used for?


Amoxicillin is a type of antibiotic drug used for treating almost any types of bacterial infections. It has been known as a common over the counter antibiotic drug and is used for killing a wide variety of bacteria that causes infections. It is more common than penicillin, and can treat infections of the skin, infection of the ears, infection of the kidney, and many others. It is commonly administered in 500 mg dosage to be taken 7 days straight, depending on the gravity of your infection.


What is methotrexate used for?


Methotrexate is a drug used to treat rheumatoid arthritis, severe psoriasis, and certain types of cancer. It can only be prescribed by your doctor so you cannot avail this drug in the pharmacy without a prescription. This drug has dangerous side effects so you should never take the drug without your doctor’s advice.

So what are the dangers of methotrexate and amoxicillin interactions?


It has been known that methotrexate and amoxicillin interactions are dangerous. Some of the serious interactions include yellowish skin, black stool, fever, fatigue, easy bruising, stomach pain, skin rash, breathing problems, and many others. The reason why methotrexate and amoxicillin interactions are dangerous because the amoxicillin prevents the kidneys from disposing methotrexate in the body. This in return causes an increase of methotrexate in the body. We all know that methotrexate have potential side effects, and if not eliminated in the body, may cause life threatening side effects.


Before you begin a treatment involving either methotrexate or amoxicillin, it is best that you consult first your doctor. There are medications that are also dangerous to combine with either methotrexate or amoxicillin. Ask your doctor about these drugs for more information. Before you can be prescribed with amoxicillin or methotrexate, inform your doctor of the other drugs or supplements you are currently taking since these might also have dangerous interactions with amoxicillin and methotrexate.

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