Often times our ailments are associated with more than one type of symptoms, and the need to combine medications is a necessity. However not all medications are safe to use together. Your doctor will often balance out the side effects of the drugs before they can prescribe them to you. If the drugs are safe to use together, your doctor will still need to monitor the effects of the drug in your body, and do series of lab tests from time to time, depending on the gravity of your ailment and the type of drugs you are prescribed to take. For example, when you take medications used for treating bacterial infections such as amoxicillin, you have to take measures and precautions about which drug is safe to be taken together with this antibiotic. Among the most dangerous combination with amoxicillin is methotrexate. So why combining methotrexate and amoxicillin is such a bad idea? What are the possible methotrexate and amoxicillin interactions? First let us take a look at the uses of each drug.